Risk Assessment Uncertainty Analysis

The National Research Council convened a committee entitled "Improving Risk Analysis Approaches Used By the U.S. EPA" to reexamine the agency's methodology and guidance. Gradient provided input on the subject of "Hypothesis-Based Weight of Evidence and its Bearing on Uncertainty Analysis in Risk Assessment;" in which concerns about current hazard identification procedures were aired. An alternative endpoint-by-endpoint approach was proposed that takes greater account of concordances (and lack of concordances) across test-animal sexes and species and between animal and human studies. The committee is considering this advice to formulate its pending recommendatio

Project Highlights

  • Hypothesis-based weight of evidence
  • Toxicity endpoints